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Customized Contact Lens Treatments for in-the-Eye Medication
Cód:
491_9783639156126
Hydrophilic polymer (polymacon, alphafilcon-A) andsilicone-based (balafilcon-A) hydrogel contactlenses, before and after surface modification byradio-frequency glow-discharge treatment (RFGDT),were used to monitor methylene blue/silver nitratedrug-surrogate uptake and elution. Infraredspectroscopy revealed modified absorption peaks,accordingly. Energy-dispersive x-ray (EDX) analysisand inductively coupled argon plasma atomic emissionspectroscopy (ICP) confirmed silver lens depotconcentrations and were employed to measured eluateconcentrations, while visible spectrophotometry andICP spectrometry monitored methylene blue and silverelution rates in static versus simulated eye-blinkingconditions. The conclusions reached are that (1)initial drug uptake of surface modified lensesincreased in this order: polymacon < alphafilcon-A Veja mais

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