Formulation and in Vitro Evaluation of Self Micro Emulsifying DDS

Editora:

KS OmniScriptum Publishing

Código:

491_9786203410822

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Empagliflozin is a sodium glucose co-transporter-2 (SGLT-2) inhibitor. SGLT2 co-transporters are responsible for reabsorption of glucose from the glomerular filtrate in the kidney. The glucuretic effect resulting from SGLT2 inhibition reduces renal absorption and lowers the renal threshold for glucose, resulting in increased glucose excretion.SMEDDS are commercially feasible, simple and convenient novel vehicles for delivery of medicaments which can enhance drug absorption with reduced systemic side effects. They can be used to optimise drug targeting without a concomitant increase in systemic absorption. Appropriate excipient selection and safety evaluation especially of the cosurfactants and Oil is crucial in the formulation of SMEDDS. They can be potential drug delivery systems for the delivery of more than one medicament simultaneously.

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